Oct 29, 2021
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Jun 20, 2016
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Category:Native Instruments
Category:Guitar performance-related software
Category:Windows multimedia softwareA follow-up study of the long-term effects of the Duchenne muscular dystrophy (DMD) gene therapy using adeno-associated virus-1-mediated gene delivery.
The efficacy of an adeno-associated virus (AAV)-1-mediated gene therapy for the treatment of Duchenne muscular dystrophy (DMD) was examined in 30 DMD patients. AAV-1 was first administered by intramuscular injections into the calves and then into the tibialis anterior, followed by serial intravenous administrations of AAV-1 every 2 months. The time-dependent increases in serum creatine kinase (CK) level, assessed by the Child-Pugh classification, were similar to those in previous reports. The outcome was satisfactory in most patients, including all 12 patients who showed serum CK elevations exceeding twice the normal range at the final follow-up. No local or systemic complications were encountered during the course of treatment. The findings indicate that AAV-1-mediated gene therapy might be an efficient treatment for DMD.The present invention relates to a differential amplifier circuit and, more particularly, to a differential amplifier circuit for use in a sampling pulse detection circuit of a lock-in amplifier.
Conventionally, for use in the sampling pulse detection circuit of a lock-in amplifier, a differential amplifier circuit is required. In a differential amplifier circuit of the prior art, the input-side differential pair and output-side differential pair are made to be of the same construction and, therefore, when a signal of a large signal level is input to the input terminal, the differential amplifier circuit is broken down ac619d1d87
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